A Flexible Route to Synthesis and Molecular Docking of Some New Quinoline Derivatives through Imine and Cyclization Processes

The current assignment depicts the structure of recent quinoline derivatives. This method begins with imine derivatives through condensation reaction ethyl 2-aminobenzoate various substituted aliphatic aldehydes and ketones in existence sodium hydroxide as a catalyst. While second step includes intra-cyclization process compounds presence base like tertiary butoxide that resolute installs hydroxyl- group on bicyclic skeleton aromatic amines. molecular docking program Flare V4.0 was applied to investigate biological activities divers produced against E.coli bacteria. Spectral data support each outputs acquired during this assignment.